Articulated arm apparatus

ABSTRACT

A hermetically sealed multi-axis articulated arm apparatus for use within a sealable isolator chamber is disclosed. In one general aspect, it comprises a rotational shaft that passes through an opening in the chamber, a sealing member disposed within the chamber for sealing the shaft to an inner surface of the chamber, interconnected hermetically sealed arm segments operably attached to the linear motion shaft; an end effector operably attached to a terminal arm segment among the arm segments, and at least one fully enclosed drive system for driving and controlling the shaft and the arm segments. The rotational shaft can further be a linear motion shaft for which the sealing member is a bellows. The materials for the parts of the apparatus exposed to the atmosphere of the chamber can be compatible with an aseptic and cleanable environment and the surfaces of the arm segments can be shaped to avoid pooling of contaminants.

FIELD OF THE INVENTION

This invention relates, in general, to pharmaceutical processing. Morespecifically, this invention relates to a multi-axis articulatedmanipulating arm apparatus.

BACKGROUND OF THE INVENTION

It is desirable for various pharmaceutical, biotechnology, and foodprocesses or operations to be performed in a sterile environment. Beforethis can occur, the process environment generally needs to be preparedwith a number of steps, such as cleaning via wipe-down and/or wash-down,and decontamination via liquid, vaporized liquid, gas and/or light-basedmethods. Generally, the process environment pressure has to bemaintained and low particle generation needs to be ensured during theprocess. In addition, limited human contact is often desirable in thesterile processes to limit contamination of product handling surfaces.

In some cases; aforementioned processes need to be contained for productintegrity and/or operator safety. Examples of such processes includeprocessing oxygen sensitive products and cytotoxic products. In suchcases, the system needs to be operated in a negative pressureenvironment to prevent egress of the process air and/or the system mayrun under an inert gas environment such as nitrogen. In addition to thecontainment requirement, the system may require particle ingress controlto prevent product contamination.

In operational settings such as laboratory or production, aforementionedrequirements are often met through employing automation systems.However, automation systems tend to have limited flexibility or cantypically meet either only sterile process requirements or onlycontainment process requirements.

Exterior surfaces of apparatuses in use for pharmaceutical,biotechnology, and food processes operations require to be smooth,impervious, free of cracks and crevices, non-toxic corrosion resistantand cleanable. Stainless steel is an example of a material that iswidely used for such surfaces. In addition to stainless steel there arevarious other materials with similar or superior characteristics.

For many years multi-axis articulated manipulating arm apparatus havebeen almost exclusively constructed using relative lightweight armsegments of machined or casted aluminum alloys. Typically these armsegments are anodized to increase corrosion resistance and surfacehardness. In some operational settings it is preferable not to usealuminum or anodized aluminum as construction material. The material isnot highly scratch resistant; it can chip on impact or shed on friction.Furthermore it is known not to be inert when exposed to oxidizing agentsthat are used for cleaning and decontamination processes.

Typically this kind of multi-axis articulated arm apparatus comprisesarm segments that have bolted plates that cover openings that provideaccess to drive mechanisms such as motors, encoders, pulleys and belts.The cover plate results in a hard to clean crevice, as do the bolts andmachine screws. The rotary joints and linear motion shafts of theseapparatuses typically are not sealed to facilitate cleaning anddecontamination. In some cases the apparatuses are required to havecomplex control systems in place to maintain system integrity.

SUMMARY OF THE INVENTION

In a first aspect, there is presented a hermetically sealed multi-axisarticulated arm apparatus for use within a sealable isolator chamber,the apparatus comprising: a shaft having a rotational axis, wherein theshaft passes through an opening in the sealable isolator chamber and isconfigured to rotate around the axis; a sealing member, including: amounting surface configured for mounting the sealing member on andhermetically sealing it to an inner surface of the sealable isolatorchamber, wherein the mounting surface and the inner surface continuouslysurround the opening in the sealable isolator chamber, a shaft sealingsurface defined by the sealing member, which surrounds and seals theshaft, a plurality of interconnected hermetically sealed arm segments,wherein one of the plurality of arm segments is a terminal arm segment,and one of the plurality of arm segments is a first arm segment operablyattached to the linear motion shaft; an end effector attached to theterminal arm segment; and at least one drive system for driving andcontrolling the shaft and the plurality of arm segments, with the drivesystem being fully enclosed within the articulated arm apparatus.

The shaft can be a linear motion shaft that is further configured tomove axially with respect to the opening along the axis. The sealingmember can include a bellows mounted between the mounting surface andthe shaft sealing surface, and the shaft sealing surface can be operablyconnected to the first arm segment. The bellows can be disposed withinthe isolator chamber. The bellows can be a stainless steel bellows.

The outer surfaces of the linear motion shaft, bellows, and arm segmentscan be stainless steel. The stainless steel can be electro-polished. Thestainless steel can be one of 304, 316 and 316L stainless steel. Thebellows can be a PTFE bellows.

At least one of the plurality of arm segments can be joined to anotherof the plurality of arm segments by a hermetically sealed rotary elbowjoint, the rotary elbow joint comprising a rotatable hub, an elbowhousing, and a radial seal member for hermetically sealing the hub tothe elbow housing. The radial seal member can comprise acircumferentially sealing part that extends axially outwards from theelbow housing along the hub to prevent contamination. Thecircumferentially sealing part can be an exposed cleanable radial lipseal. The radial seal member can comprise a plurality ofcircumferentially sealing parts. The plurality of circumferentiallysealing parts can include at least three circumferentially sealingparts.

At least one of the arm segments of the hermetically sealed multi-axisarticulated arm apparatus can comprise a stainless steel outer shellthat increases a strength to mass ratio of the at least one arm segmentsufficiently to cause the ratio to be closer to a strength to mass ratioof an aluminum arm of equivalent dimensions that is machined from asolid piece than to a strength to mass ratio of a stainless steel arm ofequivalent dimensions that is machined from a solid piece. The terminalarm segment is the one of the at least one arm segments that comprisesthe stainless steel outer shell that increases the yield strength.

An upper surface of at least one of the plurality of arm segments can beconfigured to inhibit pooling of a liquid on the articulated armapparatus and to facilitate runoff of the liquid from the articulatedarm apparatus. The upper surface can have a profile to directcontaminants off the upper surface. The profile can comprise at leastone section with a slope of at least one degree with respect to thehorizontal. A plurality of edges of at least one arm segment can beradiused to facilitate removal of liquids. The end effector can beconfigured to dispense a pharmaceutical product. The end effector can beconfigured to support a tray. The end effector can be configured tomanipulate a container closure. The end effector can also be configuredto manipulate one or more containers. The arm segment operably attachedto the linear motion shaft can be shorter than at least one other of theplurality of arm segments. At least one of the plurality of arm segmentscan be of seamless single shell design. All of the plurality of armsegments can be of seamless single shell design.

The sealed multi-axis articulated arm apparatus can be an automaticallycontrolled and reprogrammable articulated arm. The drive system can befurther operative to drive the end effector. Surfaces of the arm to beexposed to the inside of the sealable isolator chamber can be free ofslots or gaps of width less than about 10 mm.

In a further aspect, there is presented a method of manipulatingpharmaceutical products in a sealable isolator chamber, comprising:rotating a shaft that passes through an opening in the sealable isolatorchamber, moving a plurality of interconnected arm segments that areoperatively connected to the shaft to manipulate the pharmaceuticalproducts, sealing a space within the interconnected arm segments, andsealing a portion of the shaft inside the chamber. The method canfurther include the steps of translating the shaft in a series ofopposing strokes while the step of sealing a portion of the shaftmaintains a hermetic seal during the steps of translating. The step ofsealing a portion of the shaft can be performed by an element thatexpands and contracts during the steps of translating. The step ofsealing a space within the interconnected arm segments can seal a drivemechanism for moving the arm segments inside the arm segments.

BRIEF DESCRIPTION OF THE DRAWINGS

The drawings illustrate generally, by way of example, but not by way oflimitation, various embodiments discussed in the present document.

FIG. 1 is a perspective view of an articulated arm.

FIG. 2 is a perspective view of another embodiment of an articulatedarm.

FIG. 3 is a cross-sectional view of a rotating joint of an articulatedarm.

FIG. 4 is an enlarged cross-sectional segmented view of a flush-mountedo-ring seal of the rotating joint of FIG. 3.

FIG. 5 is a perspective view of a section of an articulated arm.

FIG. 6 is a perspective view of a first joint housing of an articulatedarm.

FIG. 7 is a perspective view of a second joint housing of an articulatedarm.

FIG. 8 is a perspective view of a section of an articulated arm.

FIG. 9 is a further perspective view of a first joint housing of anarticulated arm.

FIG. 10 is a further perspective view of a second joint housing of anarticulated arm.

FIG. 11 is a top view of a section of an articulated arm.

FIG. 12 is a cross-sectional view of a section of an articulated arm,the cross section taken along line 12-12 of FIG. 11.

FIG. 13 is a top view of an articulated arm within a high reach travelrange.

FIG. 14 is a top view of an articulated arm within a medium reach travelrange.

FIG. 15 is a top view of an articulated arm within a low reach travelrange.

FIG. 16 is a top schematic view of an articulated arm performing afilling operation.

DETAILED DESCRIPTION OF AN ILLUSTRATIVE EMBODIMENT

An example of an articulated arm apparatus is presented for use in asealable isolator chamber, the apparatus being compatible with variousdecontamination methods. It meets a particle generation requirement andcan be used in sterile and containment systems such as those encounteredin pharmaceuticals processing and handling environments. The apparatushas at least two arm segments capable of multi-axis operation, and hassurfaces that are free from imperfections such as pits, folds andcrevices. It avoids having top surfaces that are flat and insteadprovides profiled top surfaces, particularly sloped top surfaces.Part-to-part connections are hermetically sealed and the sealingelements are flush with the parts surfaces. The apparatus is composed ofcomponents having a single shell construction. The term “single shell”is used here to describe an enclosing mechanical object formed of asingle contiguous piece of material and within which other operativeparts made from other materials may be contained. There are no exposedparts with sharp radii, and standard machine screws and bolts areavoided. The apparatus is leak tight as regards air, process fluids, andcleaning fluids. Parts and sub-assemblies are free of slots or gaps ofwidth less than about 10 mm, which could otherwise restrict access forinspection, cleaning fluids and decontamination agents. Any shaftsmoving in and out of the containment space of the isolator do not do soto a contaminated space. All drive mechanisms are fully enclosed.

In FIG. 1 there is provided a multi-axis articulated manipulating armapparatus 100 that is compatible with various decontamination methods,meets a particle generation requirement, and can be used in sterile andcontainment systems. Articulated arm apparatus 100 comprises a base 102configured to be attached within a work area or environment, includingbut not limited to a production area, an isolator chamber, a processline, or the like. One or more motors or actuators (not shown) can beincluded in the base 102 to power and control various motions of thearticulated arm apparatus 100, as described in more detail below. Thebase 102 can further comprise a flange 103 that allows the base 102 tobe omni-directionally mounted flush with the floor, wall or ceiling ofthe work area or environment. The flange 103 can include a seal memberaround a circumference of the flange 103. This arrangement allows thebase 102 and its motor(s) to be located outside the work area orenvironment. In other embodiments, the floor, wall or ceiling of theenvironment can comprise a seal for sealing with the flange 103.

Apparatus 100 further comprises a shoulder shaft 112 attached to themotor inside the base 102. Shoulder shaft 112 can be a rotatable linearmotion shaft configured to rotate around its own axis with respect tothe base 102 and to move axially along its own axis with respect to thebase 102.

The shoulder shaft 112 can include a bellows 124 to extend and contractwith the shoulder shaft 112 to limit, if not eliminate, contamination ofthe environment within which the articulated arm apparatus 100 and/or200 is located. The bellows 124 can be configured to cover the portionof the shoulder shaft 112 that extends from the base 102 in a raised orextended position of the shoulder shaft 112, thereby serving to aid incontainment of any contaminants from within the base 102, particularlyin those situations in which shoulder shaft 112 is axially extended.

The bellows 124 is a sealable flexible container with a structurallycontiguous and compressible wall. The wall is configured to compress andextend the container along at least one direction while maintaining thecontiguity of the wall and the integrity of the seal. The wall of thecontainer can include, but is not limited to, a compressible concertinaor accordion structure having one or more segments. The segments can be,but are not limited to being, curved, folded and/or elastic. Thecontainer is typically, but not necessarily, cylindrically symmetricalaround an axis of compression and extension of the container. The wallof the bellows can be made of any suitable material such as a metal(e.g., 304, 316, or 316L stainless steel) or a polymeric material (e.g.,PTFE).

The articulated arm 100 can include a first arm segment 110 extendingfrom the shoulder shaft 112. The first arm segment 110 can include ashoulder housing 114 and an elbow housing 118, with a first arm segmenthousing 116 coupled therebetween, as will be described in more detailbelow. The shoulder and elbow housings 114 and 118 can be rigidlycoupled to the first arm segment housing 116. The shoulder housing 114can be coupled to the shoulder shaft 112 to rotate with the shouldershaft 112.

The elbow housing 118 can be included in an elbow joint 120 configuredto allow movement of a second arm segment 130 of the articulated arm 100with respect to the first arm segment 110. The elbow joint 120 will bedescribed in more detail below. The second arm segment 130 can include aframe 122 coupled to an elbow housing 132. The elbow housing 132 can beincluded in the elbow joint 120. The frame 122 can be rigidly coupled tothe elbow housing 132 to rotate with the elbow housing 132. An endeffector 104 can be coupled to the frame 122. More particularly, the endeffector 104 can be coupled to an end of the frame 122. The frame 122can include an open frame construction to increase strength whiledecreasing the inertia of the frame 122 and/or promoting better laminarairflow around the frame 122. In another embodiment frame 122 can beformed as a wire frame. In general, the inertia of the frame 122 can bedecreased, to allow greater acceleration and/or deceleration of theelbow joint 120. This reduces the load on any motors or actuatoremployed to operate second arm segment 130.

By virtue of the specific configurations of the various seals describedabove and by virtue of the sealed single shell construction of thevarious arm segments of the articulated arm apparatus 100 and 200 theapparatus hermetically seals the isolator chamber within which it isdisposed.

The end effector 104 can be configured to perform one or more operationsof the process for which the articulated arm 100 is used. In theembodiment shown in FIG. 1, the end effector 104 includes a fill needle104 used, for instance, to dispense a substance. By way of example, thefill needle 104 can dispense a pharmaceutical substance into acontainer, such as a vial, jar, or other receptacle. In other examples,the fill needle 104 can be used to dispense other substances into othertypes of receptacles. The fill needle 104 can include a supply line (notshown) to supply the substance to be dispensed to the fill needle 104.The supply line can be routed either external to the articulated arm 100or within at least a portion of the articulated arm 100. The endeffector 104 can include more than one fill needle to dispense one ormore products. The end effector 104 can include other devices inaddition to or instead of the fill needle 104, such as one or more of avacuum cup; a gripper; a sensor, including but not limited to a partpresence sensor and/or a level sensor; a tool, including but not limitedto a crimper and a screw tool, and/or another device.

In FIG. 2 a further embodiment of the apparatus of FIG. 1 is shown asidentical in all respects, except as regards the combination of thesecond arm segment 130 of FIG. 1 and the end effector 104 of FIG. 1,which are replaced by the combination of a second arm segment 230 and anend effector 204. Second arm segment 230 includes a second arm segmenthousing 222 that is coupled to the elbow housing 132. The second armsegment housing 222 is rigidly coupled to the elbow housing 132 torotate with the elbow housing 132. The end effector 204 is coupled tothe second arm segment housing 222. In an example, the end effector 204is coupled to an end of the second arm segment housing 222. Moreparticularly, the end effector 204 is rotatably coupled to the secondarm segment housing 222 with an end joint 240. End joint 240 can besimilar to the elbow joint 120. The end joint 240 includes an endhousing 234 coupled to the second arm segment housing 222 and an endeffector housing 242 coupled to the end effector 240, and rotatable withrespect to the second arm segment housing 222. The end joint 240 isdescribed in more detail below. The end effector 204 can be configuredto perform one or more operations of the process for which thearticulated arm 200 is used.

By way of example the end effector 204 can include a holder 204 used,for instance, to hold and/or maneuver a tray. The holder 204 can,selectively hold and/or maneuver a tray holding one or more containers,such as one or more vials, jars, or other receptacles. The end effector104 can include other devices in addition to or instead of the holder204, such as one or more of a vacuum cup; a gripper; a sensor, includingbut not limited to a part presence sensor and/or a level sensor; a tool,including but not limited to a crimper and a screw tool, and/or anotherdevice.

Arm segments 130 and 230, being part of embodiments shown inrespectively FIG. 1 and FIG. 2, can be described by the term “terminalarm segment”, as they are the final arm before end effector 104 and 204respectively in the series of arm segments shown in the two respectiveembodiments.

FIG. 3 shows an example embodiment of the elbow joint 120 of FIG. 1 andFIG. 2. The same description can also hold for other joints, includingbut not limited to end joint 240 in FIG. 2. Elbow joint 120 includes theelbow housing 118 of the first arm segment 110. A spindle 121 is coupledrigidly to the elbow housing 118 in order to prevent relative motionbetween the spindle 121 and the elbow housing 118. The spindle 121 iscoupled to the elbow housing 118 with fasteners 119 disposed within aninterior of the elbow housing 118 to avoid having external fasteners,which could collect and/or be the source of contaminants and couldcollect solvents or other cleansers during cleaning of the articulatedarms 100 or 200. The spindle 121 can be hollow to allow for a feedthrough for components, such as, for instance, one or more electricalwires, pneumatic tubing, vacuum tubing, or the like, or a combinationthereof. In this way, wiring, tubing, or the like can be routed from thefirst arm segment 110 toward the distal end of the articulated arms 100or 200, for instance via the elbow housing 132 of the second arm segment130 or 230, to the second arm segment 130 or 230 themselves, and/or tothe end effectors 104 or 204.

The elbow joint 120 includes a rotatable hub 126, rotatable with respectto the (outer portion) elbow housing 118. The elbow joint 120 includesbearing members 123 between the (inner portion) spindle 121 and the(middle portion) hub 126 to facilitate rotation of the hub 126. In otherembodiments, rotation of the hub 126 can be facilitated in other ways,such as, for instance, using a material with a relatively lowcoefficient of friction between the hub 126 and the spindle 121 and/orabutting surfaces the hub and the spindle and coating at least one ofthe surfaces with a material with a relatively low coefficient offriction to facilitate sliding motion between the hub and the spindle.

The elbow joint 120 includes a radial seal member 300 disposed betweenthe elbow housing 118 and the hub 126. By way of example, the radialseal member 300 can be disposed at a top edge of the elbow housing 118.The radial seal member 300 provides a seal between the elbow housing 118and the rotatable hub 126. The radial seal member 300 can comprise oneor more fingers 302 extending radially inward toward and abutting thehub 126, and axially outward along the axis of elbow joint 126 (that is,upward in FIG. 3). In an example embodiment in FIG. 3, the radial sealmember 300 comprises two fingers 302, being outer and inner fingers bothextending radially inward toward and abutting the hub 126, and axiallyoutward along the axis of hub 126 (that is, upward in FIG. 3), toprovide an increased seal between the elbow housing 118 and therotatable hub 126. The fingers 302 can have a resilient property thatmaintains the fingers 302 in contact with the hub 126 and, thereby,provide a seal.

In other embodiments the radial seal member 300 can include a singlefinger, being by default an outer finger, extending radially inwardtoward and abutting the hub 126, and extending axially outward along theaxis of hub 126. In yet other embodiments, the radial seal member 300can include a combination of an outer finger extending radially inwardtoward and abutting the hub 126, and axially outward along the axis ofthe hub 126 (that is, upward in FIG. 3) and an inner finger extendingradially inward toward and abutting the hub 126, and extending axiallyinward along the axis of the hub 126 (that is, downward in FIG. 3). Inyet further embodiments, the radial seal member 300 can comprise morethan two fingers 302.

In still further embodiments, the radial seal member can include acombination of a spring-loaded seal and one or more fingers, at leastone of the one or more fingers being an outer finger extending radiallyinward toward and abutting the hub 126, and axially outward along theaxis of the hub 126 (that is, upward in FIG. 3). By having the outerfinger 302 as a circumferentially sealing part that extends axiallyoutwards along the hub 126, contaminants and other fluids and particlesis prevented from gathering on radial seal member 300 against the hub.126. Outer finger 302, in the various embodiments described herein, canbe described by the term “exposed cleanable radial lip seal”.

In some embodiments, the radial seal member 300 can include the upperfinger 302 and an upper surface that both are pitched, or profiled witha slope, to allow liquids, such as solvents or cleansers, to drain orflow off of the radial seal member 300 rather than pooling up orotherwise collecting on or around the radial seal member 300. By way ofexample, the radial seal member 300 can include an axially-facing,externally exposed surface having no grooves, holes, crevices, or thelike, the surface being profiled to direct liquids circumferentiallyoutwardly away from the hub 126 and off of the radial seal member 300 tolimit residue being retained on or around the radial seal member 300.The radial seal member 300 can be disposed at the top edge of the elbowhousing 126, where it is relatively easily accessible. This facilitatesinspection, cleaning, maintenance, and the like. The radial seal member300 can be used to inhibit contamination of the environment within whichthe articulated arms 100 or 200 are located by leakage of lubricants anddust potentially created by drive mechanisms or other internalcomponents of the articulated arms 100 or 200. The radial seal member300 can be compact, which aids in minimizing the mass/inertia of thecomponents of the articulated arms 100 and 200.

The radial seal member 300 can be frictionally maintained in placebetween the hub 126 and the elbow housing 118. In other embodiments, theradial seal member 300 can be retained in place using various othermethods, including but not limited to a press-fit metal ring bonded tothe radial seal member 300, a threaded feature, a spring loaded barb, orthe like. The radial seal member 300 can be formed from a dry runningmaterial, including but not limited to polytetrafluroethylene (PTFE)and/or composites thereof.

With reference to FIGS. 1-3 the elbow housing 118 includes a pulley 129attached to the hub 126. Pulley 129 is configured to rotate with the hub126 (such that there is no relative rotation between the hub 126 and thepulley 129) and accommodate a belt, strap, band, chain, or the like,which is operably coupled to and driven by a motor disposed within thebase 102. By way of example, the motor within the base 102 can drive adrive shaft disposed within the shoulder shaft 112 to drive a pulleycoupled to the drive shaft. The drive shaft can be rotatableindependently of the shoulder shaft 112 to enable rotation of the hub126 independently of rotation of the shoulder shaft 112. The pulley canbe disposed within the shoulder housing 114. The belt, strap, band,chain, etc. can then be routed around both the pulleys, such thatrotation of the pulley within the shoulder housing 114 (driven by themotor within the base 102) drives the belt, strap, band, chain, etc. to,in turn drive the pulley within the elbow housing 118, thereby causingthe hub 126 to rotate with respect to the elbow housing 118. The belt,strap, band, chain, etc. can include an elastomeric belt, a toothedtiming belt, a metal band, a metal strap, a chain, a cord, a wire, orthe like. The elbow housing 118 can include a motor and, in someembodiments suitable encoders, therein to drive the hub 126, rather thanincluding the above-described pulley system.

The end joint 240 can be driven in similar manner to those describedwith respect to the elbow joint 120. By way of example, a separate driveshaft, independently rotatable with respect to the drive shaft and theshoulder shaft 112 described above, can be driven by another motorwithin the base 102. Another pulley system, similar to but independentof the above-described pulley system, can be disposed within the firstarm segment 110 to drive a shaft within, but independently rotatablefrom, the hub 126, to drive another pulley system, similar to theabove-described pulley system, within the second arm segment 230 todrive the end joint 240 in a manner similar to that described above withrespect to the elbow joint 120. The elbow joint 120 can include a motor,and, in some embodiments, suitable sensors and encoders, to drive theend joint 240 using a similar pulley system within the second armsegment 230. The end joint 240 can include a motor configured to drivethe end effector 204. Various combinations of the above-described drivesystems can be used to drive portions of the articulated arm 100 or 200.Determination of which drive system or combination of drive systems touse with the articulated arm 100 and/or 200 can depend on variousfactors. These include, but are not limited to, desired inertialcharacteristics of the articulated arms 100 and 200 and portionsthereof, the power needed to drive various portions of the articulatedarms 100 and 200, the size of various portions of the articulated arms100 and 200, and the size of the motors used for actuation of variousportions of the articulated arms 100 and 200, etc.

The elbow housing 132 of the second arm segment 130 and 230 can becoupled to the hub 126 to rotate with the hub 126. In this way, rotationof the hub 126 causes rotation of the second arm segment 130 and 230.Static seal members 310 can be used between static joints of thearticulated arms 100 and 200, such as, for instance, between the hub 126and the elbow housing 132 of the second arm segment 130 and 230. Thestatic seal member 310 can be disposed at a static joint between theelbow housing 132 of the second arm segment 130 and a elbow cap 131 ofthe elbow joint 120. Seal members similar to the static seal members 310shown in FIG. 3 can be used for other static joints between componentsof the articulated arms 100 and 200. By way of example, such static sealmembers can be used between the flange 103 of the base 102 and the floorof the environment within which the articulated arms 100 and 200 isused. Such static seal members can be used in the end joint 240 in amanner similar to that described herein with respect to the elbow joint120. A static seal member can be used between the shoulder housing 114and the shoulder shaft 112 and/or between the shoulder housing 114 and ashoulder cap 115. Such static seal members can be used for all suchstatic joints between components of the articulated arms 100 and 200. Amore detailed description of the static seal member 310 is includedbelow.

With reference to FIGS. 3 and 4 the static seal member 310 includes ano-ring type seal that is placed within an externally accessible channel,such as a channel 133 (as shown in FIG. 4) formed within a portion ofthe elbow cap 131 and a portion of the elbow housing 132. Although thepresent description specifically refers to the static seal member 310between the elbow cap 131 and the elbow housing 132, it should beunderstood that similar arrangements can be used in the other examplelocations of the articulated arms 100 and 200 for which such a staticseal member 310 can be used, such as the other example locationsreferred to above. In one embodiment, when the static seal member 310 iscaptured within the channel 133 and the elbow cap 131 is engaged withinthe elbow housing 132, a portion of the static seal member 310 extendsoutwardly from the channel 133 to be disposed at least partially withinan opening 135 formed by the elbow cap 131 and the elbow housing 132.The static seal member 310 can form a relatively tight seal between theelbow cap 131 and the elbow housing 132. In other embodiments the staticseal member 310 can extend into the opening 135 in a substantially flushmanner. That is, the static seal member 310 extends into the opening 135in a manner that creates little to no crevices, cavities, or otherfeatures that would facilitate pooling or collection of contaminants orliquids, such as solvents, cleansers, or the like.

As shown in FIG. 4, exposed surfaces of the elbow cap 131, the elbowhousing 132, and the static seal member 310 are pitched to facilitaterun off of liquids and lessen the likelihood of pooling and collectionof liquids. Also, the exposed surfaces are relatively easily accessibleto facilitate inspection and/or cleaning. The static seal member 310 canbe used to lessen, if not eliminate, trapping of contaminants, liquids,residue, etc. within static seals, for instance, through capillaryforces possible between components. Such capillary forces can bepresent, for instance, between abutting metal components, and can resultin an increased likelihood that liquids, contaminants, residue, etc. canbe drawn in between the metal components. By using the static sealmember 310 of the above examples, such capillary forces are lessened, ifnot eliminated, thereby reducing, if not eliminating, such drawing in ofliquids, contaminants, residue, etc. between statically engagedcomponents of the articulated arms 100 and 200. The static seal member310 can be formed from a dry running material, such as, for instance,PTFE and/or composites thereof. In various examples, the static sealmember 310 is relatively compact, which aids in minimizing themass/inertia of the components of the articulated arms 100 and 200.

FIGS. 5-10 show example components of the first arm segment 110. It isnoted that similar components can be used in some examples of the secondarm segment 230 (FIG. 2), although in some examples, the components ofthe second arm segment 230 can be sized differently from the componentsof the first arm segment 110. In other examples, the second arm segment130 of the articulated arm 100 (FIG. 1) can be replaced with componentssimilar to the components of the first arm segment 110. As such, thedescription below can be applied to such examples even though thedescription refers to the first arm segment 110.

Referring now to FIGS. 5-7, the first arm segment 110 includes the firstarm segment housing 116, the shoulder housing 114, and the elbow housing118. The first arm segment housing 116 can include a substantiallyrectangular tube, welded segments, or formed sheet material withsubstantially concavely shaped ends to accommodate the substantiallycylindrically shaped shoulder and elbow housings 114 and 118. One orboth of the shoulder and elbow housings 114 and 118 are machined. Thefirst arm segment housing 116 can include tapered sidewalls to decreasea cross-sectional area of the first arm segment housing 116 from one endof the first arm segment housing 116 to the other end of the first armsegment housing 116. A thickness of the first arm segment housing 116can be determined by the load carrying capacity of the articulated arm100 and 200 and material strength calculations. The shoulder and elbowhousings 114 and 118 include windows within their sidewalls toaccommodate pulley systems, such as those described above. The shoulderand elbow housings 114 and 118 are attached to the first arm segmenthousing 116. In particular, the shoulder and elbow housings 114 and 118can be rigidly attached to the first arm segment housing 116. Moreparticularly, the shoulder and elbow housings 114 and 118 can be weldedto the first arm segment housing 116.

Referring now to FIGS. 8-10, the first arm segment can include a firstarm segment housing 116′, a shoulder housing 114′, and an elbow housing118′. The first arm segment housing 116′ can include a substantiallyrectangular tube or formed sheet material with closed ends andsubstantially circularly shaped holes through a top surface and a bottomsurface proximate the ends to accommodate the substantiallycylindrically shaped shoulder and elbow housings 114′ and 118′. One orboth of the shoulder and elbow housings 114′ and 118′ can be machined.The matter of choice of materials and fabrication techniques isdiscussed in more detail below.

The first arm segment housing 116′ can include tapered sidewalls todecrease a cross-sectional area of the first arm segment housing 116′from one end of the first arm segment housing 116′ to the other end ofthe first arm segment housing 116′. A thickness of the first arm segmenthousing 116′ can be determined by the load carrying capacity of thearticulated arm and material strength calculations. In some exampleembodiments, the shoulder and elbow housings 114′ and 118′ can includewindows within their sidewalls to accommodate pulley systems, such asthose described above. The shoulder and elbow housings 114′ and 118′ areattached to the first arm segment housing 116′. In particular, theshoulder and elbow housings 114′ and 118′ can be rigidly attached to thefirst arm segment housing 116′. More particularly, the shoulder andelbow housings 114′ and 118′ can be welded to the first arm segmenthousing 116′.

With reference to FIGS. 11 and 12, the first arm segment housing 116 caninclude a profiled upper surface 116A to enable contaminants, liquids,or other substances to run off. The upper surface 116A can be profiledto be curved, pitched, sloped or otherwise angled. That is, the uppersurface 116A can be configured to inhibit pooling or collection of amaterial thereon. Other surfaces of the articulated arm apparatus 100and 200 can be similarly profiled to be curved, pitched, sloped orotherwise angled. Other substantially horizontally-disposed surfaces ofthe articulated arm apparatus 100 and 200 can be similarly profiled tobe curved, pitched, sloped or otherwise angled. For instance, an uppersurface of the second arm segment housing 222 (FIG. 2) can be profiledto be curved, pitched, sloped or otherwise angled in a manner similar tothat described above with respect to the first arm segment housing 116.

In other embodiments, an upwardly facing surface of the elbow cap 131(FIG. 3) can be profiled to be curved, pitched, sloped or otherwiseangled in a manner similar to that described above with respect to thefirst arm segment housing 116.

In yet further embodiments, the shoulder cap 115 (FIGS. 1 and 2) and anend cap 241 (FIG. 2) can be profiled to be curved, pitched, sloped orotherwise angled in a manner similar to that described above withrespect to the first arm segment housing 116.

In still further embodiments, upwardly facing surfaces of the endeffectors 104 and 204 (FIGS. 1 and 2) can be profiled to be curved,pitched, sloped or otherwise angled in a manner similar to thatdescribed above with respect to the first arm segment housing 116.

In yet other embodiments, an upwardly facing surface of the flange 103of the base 102 (FIGS. 1 and 2) can be profiled to be curved, pitched,sloped or otherwise angled in a manner similar to that described abovewith respect to the first arm segment housing 116.

More generally, the flange 103 and the bellows 124 form a sealing memberthat provides a sealing surface to directly or indirectly seal againstan interior surface of the chamber and a sealing surface that seals theshaft. And while the separate flange built into the body shown in thedrawings is presently preferred, the sealing member can also be definedin other ways. The bellows can have an integral flange, for example,which can interface directly with the interior surface of the chamber,thus eliminating the need for a separate flange and body. In oneembodiment, a simple seal, such as a spring-loaded seal, can instead actas the sealing member.

In various embodiments, any surface of the articulated arm apparatus 100and 200 where collection or pooling of a substance could result, can beprofiled to be curved, pitched, sloped or otherwise angled in a mannersimilar to lessen the likelihood of such pooling or collection andfacilitate the runoff, draining, or removal of such a substance.

When any of the above profiled surfaces is angled, the angle of thesurface is preferably 1 degree or more with respect to the horizontal.The edges of the arm segments can be radiused to facilitate removal ofliquids.

External components of articulated arms 100 and 200 can be constructedas a structural skin that provides the required structural strength;alternatively the components can constructed as a single shell havingone or a plurality of internal structures that provide part or all ofthe required structural strength.

External components of the articulated arms 100 and 200 can be formedfrom one or more rigid materials. In particular, the external componentsof the articulated arms 100 and 200 (other than at least portions of theradial and static seal members 300 and 310) can be formed from ametallic material or metallic alloy.

In most embodiments the outer surfaces of the linear motion shaft, base,bellows and arm segments are made out of stainless steel. Stainlesssteel of grade 304, 316 or 316L is the preferred material ofconstruction because it these are the most widely used grades ofstainless steel in construction of apparatuses for use inpharmaceutical, biotechnology, and food processes or operations.Stainless steel is usually known to be an acceptable material for theparticular process or operation.

The surface finish of construction materials is another majorconsideration in materials choice. Food equipment standards requireground or polished surfaces to meet a number 4 finish and unpolishedsurfaces to meet a number 2B mill finish. For pharmaceutical equipmentthere are no such predetermined standards. The surface finish can varyper process and per product, and has to be determined by cleaningvalidation studies. For. decontamination of equipment by gaseous agentssuch as hydrogen peroxide, formaldehyde, chlorine dioxide, surfaces witha wide range of surface finish ranging from 2B up to mechanical mirrorpolish or electropolish are known to work effectively.

Stainless steel has a relative low yield strength to density ratio incomparison to some other materials such as aluminum or titanium. Thiscould be of concern to applications of robotic arm apparatuses thatrequire very low moments of inertia, as may be required to facilitatehigh acceleration and deceleration rates. If required the strength todensity ratio disadvantage can be mitigated by various arm segmentfabrication methods outlined below:

Stainless steel single shell arm segments can be fabricated by combiningtwo or more machined parts by welding. Stainless steel machined partsthat exceed micro-machining size and cost limitations typically have aminimum wall thickness of approximately ⅛″. The weight of the assemblycan be significantly reduced by replacing some or all of the surfaces inthe assembly by stainless steel materials with wall thickness thinnerthan ⅛″. Examples of suitable thin walled materials are pipe, tubing,sheet metal or shim stock. These materials can be formed by a wide rangeof methods such as bending, stamping, spinning, deep drawing, rolling,hydroforming and or cutting to the dimensions required to fit theassembly. In addition some or all of the surfaces can be replaced bycast thin walled stainless steel parts.

Welding of thin wall stainless steel assemblies is typically complicatedby deformations by warpage due to heat required to fuse the differentparts, and due to the heat required to add stainless steel fillermaterial. These deformations can be compensated for by final machiningof the assembly after welding; alternatively a low heat weldingtechnique such as laser or electron beam welding can be used.

In view of the above stainless steel arm segment can be fabricated withappropriate wall thickness that meets the strength and fatiguespecifications required for a structural single shell for use in anarticulated arm apparatus. If the weight and moment of inertia of sucharm segment would exceed moment of inertia limitations, the single shellcould be changed to a non-structural single shell with one or aplurality of inner structural structures.

Low moments of inertia are beneficial for any articulated arm apparatus,allowing higher acceleration and deceleration; smaller sized motors;smaller sized drive belts; and consequent smaller sized apparatuses tohouse all the these parts. The reduced size and footprint of theapparatus is also an advantage during cleaning and decontamination.

In some embodiments, the external components of the articulated arms 100and 200 (other than at least portions of the radial and static sealmembers 300, 310) can be formed from a material different fromstainless, including but not limited to titanium, a titanium alloy andan amorphous metal alloy. In yet other embodiments, the externalcomponents of the articulated arms 100 and 200 (other than at leastportions of the radial and static seal members 300 and 310) can beformed from a low density metal such as aluminum alloy or compositematerial which outer surface is fully coated with an impervious,non-flaking, non-chipping, corrosion resistant material such as PTFE,ceramic material or an amorphous metal alloy.

In further embodiments, the external components of the articulated arms100 and 200 (other than at least portions of the radial and static sealmembers 300 and 310) can be formed from a combination of two or morematerials, including, but not limited to stainless steel, fully coatedmaterials, titanium, amorphous metal alloy, or the like.

In various example embodiments, external components of the articulatedarms 100 and 200 can include specific surface characteristics that areconducive of various gas and vapor decontamination methods. In furtherexample embodiments, maintaining minimum arm segments 110 and 130 (or110 and 230, or 130 and 230) inter-distances can enhance various gas andvapor decontamination processes (in addition to moving arms duringdecontamination processes) and decrease, if not eliminate, pooling andtrapping of cleaning agents, solvents, and other particles. Moreover,adapting frame style arm segment 130 in the articulated arm 100 furtherenhances various gas, vapor, and light-based decontamination process bydecreasing or minimizing shadowing and narrow channels where aircirculation dead zones can be created.

In FIGS. 13-15 various positions of the articulated arm 100 are shown.FIG. 13 shows an example of the articulated arm 100 within a high reachtravel range. FIG. 14 shows an example of the articulated arm 100 withina medium reach travel range. FIG. 15 shows an example of the articulatedarm 100 within a low reach travel range. Movement of the articulated arm100 from the medium reach travel range to the high reach travel range isaccomplished primarily with rotation of the elbow joint 120 with only arelatively limited amount of rotation of the shoulder shaft 112. Thisconfiguration allows for the articulated arm 100 to relatively quicklytransition between the medium and high reach travel ranges. As such, thearticulated arm 100 can be desirable for tool trajectories that can beplanned such that they require relative small rotations of the shouldershaft 112 and relative large rotations of the elbow joint 120.

As shown in FIGS. 13-15, the second arm segment 130 includes a differentlength than that of the first arm segment 110. The second arm segment130 is longer than the first arm segment 110, such that the end effector104 can clear the shoulder housing 114 and the shoulder cap 115. In thisway, the second arm segment 130 can be fully rotated without the concernof contacting the end effector 104 with the shoulder housing 114 and/orshoulder cap 115 and potentially damaging the end effector 104.

FIG. 16 shows an example pharmaceutical fill application of articulatedarm 100 filling containers positioned on a rectangular tray. In anexample, the containers need not be packed in a tight array. In anexample, the containers can all be filled in tool trajectories requiringrepetitive, relatively short rotations of the shoulder shaft 112 incombination with relatively large rotations of the elbow joint 120. Inan example, a vision system and a path planning algorithm can be usedfor tool trajectories that are driven by random positioned objects, suchas the containers such shown in FIG. 16.

Although the above examples of the articulated arms 100 and 200 includejoints that rotate about vertical axes, such articulated arms caninclude joints rotatable about axes other than vertical axes or inaddition to being rotatable about vertical axes. As such, it iscontemplated herein that the joints of the articulated arm examplesdescribed herein be rotatable about variously oriented axes, dependingupon various factors, including, but not limited to desired movement ofthe articulated arm, working space size and/or configuration, task orprocess to be performed, etc.

The articulated arms 100 and 200 and systems described herein can beused for manufacturing processes in isolator systems in use inapplications, such as pharmacy automation, biotechnology processautomation, Manufacturing of food and pharmaceutical products, assemblyand packaging of diagnostic tests and medical devices, and the like. Inan example, the systems can be used in the handling and manipulating ofsterile pharmaceutical containers, closures, seals, and other materialsfor product manufacturing systems, such as aseptic filling andprocessing systems.

The articulated arms 100 and 200 and/or systems described herein providefor cleanable and decontaminatable static seals for use in food andpharmaceutical systems. In another example, the articulated arms 100 and200 and/or systems described herein provide for cleanable anddecontaminatable rotating seals for use in food and pharmaceuticalsystems. In another example, the articulated arms 100 and 200 and/orsystems described herein provide for relatively highly cleanablearticulated systems and articulated arms. These articulated arms 100 and200 enable multi-axis manipulation of products, parts, and/or packagingin food and/or pharmaceutical facilities. The articulated arms 100 and200 and/or systems described herein can be a fully sealed 3-axis robotto enable multi-axis manipulation of products, parts, and/or packagingin contamination critical environments, such as, for instance, food andpharmaceutical manufacturing facilities. The articulated arms 100 and200 allow for automated manufacturing and test processes and can lessen,if not eliminate, the need for human manipulation in the processed. Anyor all components of the articulated arms 100 and 200 and/or systemsdescribed herein can be cleaned by solvents, aqueous solutions of acids,bases, detergents, and the like and/or can be decontaminated by chemicalmeans, such as, for instance, by hydrogen peroxide vapor exposure.

The articulated arms 100 and 200 and/or systems described herein providefor externally disposed components having a decreased number of crevicesand cavities and or a decreased number of protrusions. Such components,in various examples, allow for increased cleaning of the components;increased decontamination of the components, for instance, usingchemical decontamination, such as, for instance, using vaporous hydrogenperoxide. Such components, in some examples, allow for increased visualinspection. Such components, in some examples, allow for increasedinspection by aided methods, such as, for instance, riboflavin residuetesting.

In some embodiments, the articulated arms 100 and 200 and/or systemsdescribed herein provide sealed stainless steel articulated arms for usein isolator systems. In some embodiments components of the articulatedarm include relatively few or no sharp corners and relatively few or nounsealed metal-to-metal joints and are of seamless single shell design.

In some embodiments, the rotating joints and static joints are sealedand designed in such a way that few to no crevices exist in the sealedjoints. In an example, most, if not all, surfaces of the articulatedarms 100 and 200 are self-draining and relatively easily accessible forcleaning, inspection, decontamination, and the like.

The drive systems for driving and controlling the linear motion shaft,the plurality of arm segments, and the end effector can be fullyenclosed within the articulated arm apparatus to prevent any debris orcontamination associated with such drive systems from entering theworking space of the isolator chamber.

The present inventors believe that the articulated arms 100 and 200and/or systems described herein are advantageous for many reasons,including at least the following reasons. For instance, the articulatedarms 100 and 200 and/or systems described herein can reduce the risk ofoperator exposure when handling potent compounds and/or cytotoxicmaterials. The articulated arms 100 and 200 and/or systems describedherein can lessen the likelihood of cross contamination when usingnon-dedicated equipment. Also, it is believed that the articulated arms100 and 200 and/or systems described herein provide for increasedrepeatability of processes for cleaning and/or decontamination ofcomponents. Additionally, it is believed that the seals and othercomponents of the articulated arms 100 and 200 and/or systems describedherein allow for cleaning by an automated process and/ordecontamination, for instance, using chemical decontamination usinghydrogen peroxide vapor or the like.

Further, the articulated arms 100 and 200 and/or systems describedherein can provide for locating an end effector at a relatively highspeed. It is also believed that the construction of the components ofthe articulated arms 100 and 200 and/or systems described herein allowsfor decreased weight and, in turn, inertial characteristics of thecomponents. For at least this reason, the present inventors believe thatthe articulated arms 100 and 200 and/or systems described herein can beadvantageously used in systems requiring relatively frequent high speedtravel and relatively frequent directional changes. Also, thearticulated arms 100 and 200 and/or systems described herein can bescaled to any desired reach and/or load-carrying capacity.

The articulated arm 100 or 200 can be employed in a filling systemconfigured to fill containers with a product. The product can be aliquid product, a pharmaceutical product or a potentially toxic orotherwise harmful product. The filling system can be configured tolocate, target, and fill containers within a tray or nest. Many types ofcontainers are contemplated herein, including, but not limited to vials,syringes, bottles, beakers, test tubes, etc. The filling system includesa chamber configured to maintain desired environmental conditions. Thechamber can be an isolator chamber capable of maintaining an asepticenvironment within the chamber.

The filling system allows for robotic filling of containers. In anexample, the system allows for the aseptic filling of vials andsyringes, particularly for small and developmental runs of potent and/ortoxic materials. The system can provide an automated aseptic fillingsystem that does not require the use of unique or specialized componentsfor various container sizes. The system allows for filling of varioussized or shaped containers, provided a recognizable container openingexists. Also, the filling system can include an optical system to allowfor inspection of containers prior to filling, thus reducing thepossibility of rejection due to container defects post-filling.Additionally, pre-fill inspection can be achieved with an optical sensorwithout the use of additional parts or manual steps. In one example, thesystems are configured to be minimally disruptive to sterilized airflowscommonly used in aseptic filling.

In this way, randomly placed containers can be filled automatically,potentially resulting in labor and time savings. The optical sensorsystem allows for precision targeting and filling of containers, whichcan lead to reduced potential for spills of high-value or toxicmaterials that could require containment. Because the filling system iscapable of handling various products and variously sized and shapedcontainers, the filling system is relatively rapidly adaptable for newproducts and processes. Also, by using optical sensors in some examples,the system allows for reduction of product losses due to inclusion of apre-fill inspection of containers. Additionally, because the system isrelatively small and contained it provides for relatively easy cleaningof surfaces and parts. Moreover, by being configured to accept variouslysized and shaped containers, the system allows for reduced cost becauselittle or no container-specific parts are needed.

In one embodiment, the hermetic sealing provided by the articulated armis sufficient to satisfy predetermined requirements according to ISOstandard ISO10648-2, entitled “Containment Enclosures Part2—Classification According to Leak Tightness and Associated CheckingMethods.” Specifically, the sealing is preferably sufficient to satisfyClass 3, or more preferably Class 2, or even more preferably Class 1. Inanother embodiment, the hermetic sealing provided by the articulated armis sufficient to satisfy predetermined requirements according to PDAJournal of Pharmaceutical Science and Technology Technical Report no 34,entitled “Design And Validation of Isolator Systems for theManufacturing and Testing of Health Care Products” (Sept/Oct 2001). Bothof these documents are herein incorporated by reference.

NOTES

The drawings and the associated descriptions are provided to illustrateembodiments of the invention and not to limit the scope of theinvention. Reference in the specification to “one embodiment” or “anembodiment” is intended to indicate that a particular feature,structure, or characteristic described in connection with the embodimentis included in at least an embodiment of the invention. The appearancesof the phrase “in one embodiment” or “an embodiment” in various placesin the specification are not necessarily all referring to the sameembodiment. As used in this disclosure, except where the contextrequires otherwise, the term “comprise” and variations of the term, suchas “comprising,” “comprises” and “comprised” are not intended to excludeother additives, components, integers or steps.

In the foregoing specification, the invention has been described withreference to specific embodiments thereof. It will, however, be evidentthat various modifications and changes may be made thereto withoutdeparting from the broader spirit and scope of the invention. Thespecification and drawing are, accordingly, to be regarded in anillustrative rather than a restrictive sense. It should be appreciatedthat the present invention should not be construed as limited by suchembodiments.

From the foregoing description it will be apparent that the presentinvention has a number of advantage, some of which have been describedherein, and others of which are inherent in the embodiments of theinvention described or claimed herein. Also, it will be understood thatmodifications can be made to the device, apparatus and method describedherein without departing from the teachings of subject matter describedherein. As such, the invention is not to be limited to the describedembodiments except as required by the appended claims.

PARTS LIST

-   100 articulated arm apparatus-   102 base-   103 flange-   104 fill needle-   110 first arm segment-   112 shoulder shaft-   114 shoulder housing-   114′ shoulder housing-   115 shoulder cap-   116 first arm segment housing-   116A upper surface-   116′ arm segment housing-   118 elbow housing-   118′ elbow housing-   119 fasteners-   120 elbow joint-   121 spindle-   122 end effector-   123 bearings-   124 bellows-   126 rotatable hub-   129 pulley-   130 second arm segment-   131 elbow cap-   132 elbow housing-   133 channel-   135 opening-   200 articulated aim apparatus-   204 end effectors-   222 second arm segment housing-   230 second arm segment-   234 end housing-   240 end joint-   241 end cap-   242 end effector-   300 radial seal-   302 fingers-   310 static seal

What is claimed is:
 1. A hermetically sealed multi-axis articulated armapparatus for use within a sealable isolator chamber configured tomaintain an aseptic condition, the apparatus comprising: a shaft havinga rotational axis, wherein the shaft passes through an opening in thesealable isolator chamber and is configured to rotate around the axis,the shaft raising a shaft joint, the shaft joint having an outer housingportion, a middle shaft portion, and an inner spindle portion, the innerspindle portion configured to rotate; a sealing member, including: anexposed cleanable radial seal disposed and extending radially betweenthe outer housing portion and the middle shaft portion, a mountingsurface configured for mounting the sealing member on and hermeticallysealing it to an inner surface of the sealable isolator chamber, whereinthe mounting surface and the inner surface continuously surround theopening in the sealable isolator chamber to maintain a hermeticallysealed condition with the outer housing portion, a plurality ofinterconnected hermetically sealed arm segments, wherein one of theplurality of arm segments is a terminal arm segment, and one of theplurality of arm segments is a first arm segment operably attached tothe shaft; an end effector attached to the terminal arm segmentconstructed and adapted to perform aseptic pharmaceutical containerhandling applications within the isolator chamber; and at least onedrive system for driving and controlling the shaft and the plurality ofarm segments, with the drive system being fully enclosed within thearticulated arm apparatus.
 2. The apparatus of claim 1, wherein the armsegment operably attached to the shaft is shorter than at least oneother of the plurality of arm segments.
 3. The apparatus of claim 1,wherein at least one of the plurality of arm segments is of seamlesssingle shell design.
 4. The apparatus of claim 1, wherein all of theplurality of arm segments is of seamless single shell design.
 5. Theapparatus of claim 1, wherein the sealed multi-axis articulated armapparatus is an automatically controlled and reprogrammable articulatedarm.
 6. The apparatus of claim 1 wherein the drive system is furtheroperative to drive the end effector.
 7. The apparatus of claim 1 whereinsurfaces of the arm to be exposed to the inside of the sealable isolatorchamber are free of slots or gaps of width less than about 10 mm.
 8. Theapparatus of claim 1, wherein the cleanable radial seal is an exposedcleanable radial lip seal.
 9. The apparatus of claim 1, wherein theinner shaft housing includes a cap, and the sealing member includes asecond static seal disposed between the inner shaft housing and the cap.10. The apparatus of claim 1, wherein at least one of the plurality ofarm segments is joined to another of the plurality of arm segments by ahermetically sealed rotary elbow joint, the rotary elbow jointcomprising a rotatable hub, an elbow housing, and a radial seal memberfor hermetically sealing the hub to the elbow housing.
 11. The apparatusof claim 10, wherein the radial seal member comprises acircumferentially sealing part that extends axially outwards from theelbow housing along the hub to prevent contamination.
 12. The apparatusof claim 11, wherein the circumferentially sealing part is an exposedcleanable radial lip seal.
 13. The apparatus of claim 12, wherein theradial seal member comprises a plurality of circumferentially sealingparts.
 14. The apparatus of claim 13, wherein the plurality ofcircumferentially sealing parts include at least three circumferentiallysealing parts.
 15. The apparatus of claim 1, wherein at least one of thearm segments comprises a stainless steel outer shell that increases astrength to mass ratio of the at least one arm segment sufficiently tocause the ratio to be closer to a strength to mass ratio of an aluminumarm of equivalent dimensions that is machined from a solid piece than toa strength to mass ratio of a stainless steel arm of equivalentdimensions that is machined from a solid piece.
 16. The apparatus ofclaim 15, wherein the terminal arm segment is the one of the at leastone arm segments that comprises the stainless steel outer shell thatincreases the yield strength.
 17. The apparatus of claim 1, wherein anupper surface of at least one of the plurality of arm segments isconfigured to inhibit pooling of a liquid on the articulated armapparatus and to facilitate runoff of the liquid from the articulatedarm apparatus.
 18. The apparatus of claim 17, wherein the upper surfacehas a profile to direct contaminants off the upper surface.
 19. Theapparatus of claim 18, wherein the profile comprises at least onesection with a slope of at least one degree with respect to thehorizontal.
 20. The apparatus of claim 1, wherein a plurality of edgesof at least one arm segment are radiused to facilitate removal ofliquids.
 21. The apparatus of claim 1, wherein the end effector isconfigured to dispense a pharmaceutical product.
 22. The apparatus ofclaim 1, wherein the end effector is configured to support a tray. 23.The apparatus of claim 1, wherein the end effector is configured tomanipulate a container closure.
 24. The apparatus of claim 23, whereinthe end effector is also configured to manipulate one or morecontainers.